|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
With rs8099917, HCV genotype 1b patients had a significantly lower frequency of the favourable genotype (86.6 %) compared with healthy controls (91.7 %), and HCV genotype 2a patients had an intermediate frequency (89.9 %).
|
21228123 |
2011 |
|
rs179008
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Whereas hepatic viral load and expression of genes known to be induced in chronic HCV infection were not found to differ in patients with wild-type or variant TLR7 rs179008 genotype, significant lower gene expression of interleukin-29 (IL-29)/lambda(1) interferon (IFN-λ(1)) and both of its receptor subunits was found for T homo- and hemizygous patients.
|
20872712 |
2010 |
|
rs5744069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively].
|
26455634 |
2015 |
|
rs1013151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively].
|
26455634 |
2015 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We used RNA sequencing (RNA-Seq) to examine whether IFNL4 genetic variation (rs368234815) modulates ISG expression in peripheral blood mononuclear cells (PBMC) during chronic HCV infection.
|
29165633 |
2018 |
|
rs4898
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We used PCR to analyze 188 patients with HCV-related liver disease (95 with chronic hepatitis and 93 with cirrhosis) for TIMP-1 372 T/C and TIMP-2 -418 G/C polymorphisms.
|
23563628 |
2013 |
|
rs8103142
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We tested the association of spontaneous clearance and three single nucleotide polymorphisms (SNPs) near the Interferon-lambda 3 (IFNL3) gene (rs12979860, rs8099917, functional variant rs8103142) and compared the SNP frequencies between HIV-HCV co-infected whites and Aboriginals from the Canadian Co-infection Cohort.
|
25803108 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We sought to determine the prevalence of SNP IL-28B rs12979860 C/C and non-C/C (C/T plus T/T) genotypes in HCV-related cryoglobulinemic vasculitis (CV), as compared with HCV-positive patients without CV.
|
24293567 |
2014 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We report the identification of a novel TT/-G polymorphism in the CpG region upstream of IL28B, which is a better predictor of HCV clearance than rs12979860.
|
23712427 |
2013 |
|
rs2596542
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA).
|
23024757 |
2012 |
|
rs4986938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We provide here the first report that rs498</span>6938 in the ESR2 gene played a potential sex-specific role in the etiology of HCV infection</span> in a high-risk Chinese Han population, suggesting that ESR2 is a candidate susceptibility gene for HCV infection and viral clearance.
|
25261585 |
2014 |
|
rs2596542
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We previously identified the association of SNP rs2596542 in the 5' flanking region of the MHC class I polypeptide-related sequence A (MICA) gene with the risk of HCV-induced HCC.
|
23593449 |
2013 |
|
rs944459
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed logistic regression analysis to explore the associations between rs1256049, rs4986938 and rs944459 polymorphisms of the estrogen receptor 2 gene (ESR2) and HCV infection outcomes.
|
25261585 |
2014 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the role of IL28B variations (rs8099917 and rs12979860) in response to IFN-based treatment and evaluated its association with the risk of the null virological response (NVR) in HCV /HBV dually-infected patients.
|
24147097 |
2013 |
|
rs35761398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the effects of CNR2 rs35761398 in patients with hepatitis C virus (HCV) infection.
|
23707465 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the distribution of HCV genotypes and single-nucleotide polymorphisms (SNPs) of IL28B (rs12979860 and rs8099917) in Pakistani population.
|
25703417 |
2015 |
|
rs179019
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified the association of TLR7 rs3853839C allele, haplotype CC and haplotype AC (rs179019/rs3853839) with protection against HCV persistence in Chinese females (OR=0.49, 95% CI=0.29-0.81, P=0.01 for rs3853839 GC; OR=0.29, 95% CI=0.11-0.75, P=0.01 for rs3853839 CC; OR=0.51, 95% CI=0.38-0.77, P<0.01 for haplotype CC; OR=0.29, 95% CI=0.10-0.88, P=0.03 for haplotype AC).
|
25034660 |
2014 |
|
rs616589
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified 2 SNPs (rs3792323 [A/T] and rs616589 [G/A]), located in intron 2 of mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3) that were associated with the outcome of IFN therapy in patients infected with hepatitis C virus (HCV) genotype 1b (P = 4.6 x 10(-5) and 4.8 x 10(-5), respectively).
|
19208361 |
2009 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have determined the rs12979860 single nucleotide polymorphism (SNP) upstream IL28B gene in two groups of patients with HCV-induced chronic liver disease: 1) 268 patients (159 men) with biopsy-proven chronic hepatitis C, to analyse its relation with biochemical, virological and histological features; and 2) 134 patients (97 men) with HCV-related hepatocellular carcinoma.
|
22666430 |
2012 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the rs368234815 polymorphism in 87 patients with chronic HCV by PCR sequencing and PCR-RFLP methods, simultaneously.
|
28057801 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the rs8099917 single-nucleotide polymorphism in 351 hepatitis C-associated HCC patients without history of IFN-based treatment, and correlated the age at onset of HCC in patients with each genotype.
|
23689989 |
2014 |
|
rs3775291
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the HCV genotype 1 responder genotypes at rs12979860 and rs8099917 did not associate with sustained virological response to PEG-IFN/ribavirin therapy.
|
21374656 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the HCV genotype 1 responder genotypes at rs12979860 and rs8099917 did not associate with sustained virological response to PEG-IFN/ribavirin therapy.
|
21374656 |
2011 |
|
rs1801132
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We first report that these SNPs (rs2077647, rs9340799, rs2234693, rs1801132 and rs2228480) in ERα can influence the outcomes of HCV infection in a high-risk Chinese population.
|
24395301 |
2014 |